Peter Attia· MD
and actually inflammation all these things are kind of upstream apart activation so the more that's happening the more parts being activated so you kind of have you have nad going there
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and actually inflammation all these things are kind of upstream apart activation so the more that's happening the more parts being activated so you kind of have you have nad going there
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Chronic inflammation increases NAD⁺ consumption, effectively placing the NAD⁺ system “under attack.”
Diet and lifestyle matter because chronic inflammation constantly drains your NAD reserves. Supplements alone won't effectively counteract this if the underlying inflammation isn’t addressed first.
The second one is we all have in our body a so-called salvage pathway for NAD, because NAD turns over. There’s this so-called salvaged pathway that allows it to be recycled back to…so we can get NAD from the food, but also we salvage the one that we utilize, and the salvage pathway has been shown to becoming paralyzed while you age. There’s an enzyme called NAMPT that has received a lot of attention. That enzyme tends to be inhibited by chronic inflammation and a high-fat diet.
as you get older, you're losing the ability to make NAD, but you're also chewing it up. And as it gets worse and worse as you get older, the immune system is a big drain on NAD, and actually, so is DNA repair with the activation of PARPs.
And once you drain NAD a little bit, then your PARPs and your immune system won't work, but then they'll need more NAD because you'll get more damage. And this is a positive feedback in a bad way so that once you start going down the NAD decline, the cells just start to need more, and more, and more with accumulating DNA damage.
The complete answer as to why nad levels decrease with age is still an open question but there are a few things that we do know chronic inflammation and immune activation to processes that consume nad tend to go up with age and with them our need for DNA repair placing an immense demand on the nad pool meanwhile our ability to produce and recycle nad also decreases with age