The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
nad is a carrier of hydrogen around from protein to protein and nad goes from nad plus you might have seen nad plus is the one that people like to boost but nad plus is converted by the cell into nadh right h is a hydrogen molecule and it's just what we call a hydrogen carrier
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the classical teaching is that nad is an electron carrier when you have two electrons that's gonna be in what's called the NADH form and if you don't have those two electrons it's in the oxidized form which is the nad form that's another way of holding the energy that can catalyze reactions what we're learning over the last few years is that in addition to this role as an electron carrier the nad itself can be used as a substrate for other reactions outside of the mitochondria or inside outside of its role as an electron carrier okay
so nad is a cofactor for many metabolic reactions where it gets converted between nad which is the oxidized form of the coenzyme and nadh which is the reduced form uh many many different metabolic reactions use nad in that way including the electron transport chain including the electron transport chain and glycolysis and fermentation