The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the sirtuins use nad they make nicotinamide as a byproduct so like in any reaction in chemistry if you put in if you put in things on the back end if you put in the you know the products it could inhibit the reaction is that right
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he found the first so - an inhibitor and it was nicotinamide and so we published that in 2002
nicotinamide is to get nerdy is the product of the reaction it takes an ad cleaves it oh I got it so it's just a negative feedback so we struggled with that we couldn't get any d2 going to cells it's too big even with mammalian cells is difficult as we were looking at ways to make more nad in the cell