Peter Attia· MD
I would say there could be multiple different triggers for it and I remember once even looking it up and finding sort of an old esoteric paper about topical niacin I believe I think it was in the form of niacin that could improve rosacea I said before I think that the skin is one of the areas where I would expect to see fast results and so it's this question of how do you do you pick the right people and design the right study to see an effect like that and so that's interesting maybe a rosacea endpoint in a clinical study would have good results do it yeah but what I'm basically taking away from you is IV and AD is not a great idea just on on the principles we've described that does not seem to be the way you want to administer it it's much better to build up and a hepatic reservoir of nicotinamide that's converted through the NR that you can then slow trickle into circulation as needed is probably a better bet