High doses of nicotinamide should be avoided unless the patient has cancer, as it inhibits sirtuins. — Whalespan
High doses of nicotinamide should be avoided unless the patient has cancer, as it inhibits sirtuins.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“but I've never taken the risk of if I look at a bottle of vitamins and it says there's a high dose of me niacinamide or nicotinamide I put it back because I'm not going to take the risk that even in my throat in my mouth in my gut I'm not going to inhibit the sirtuins”
“but um i've never taken the risk of if i look at a bottle of vitamins and it says there's a high dose of niacinamide or nicotinamide i put it back because i'm not going to take the risk that even in my throat in my mouth in my gut i'm not going to inhibit the sirtuins”
“nicotinamide we showed back in 2002 is a really effective inhibitor of the sirtuins which are enzymes that you want to keep on it's the whole point of raising an ad and so we try to avoid nicotinamide while raising an ad”
“and there's actually reasons to avoid taking high doses nicotinamide unless you're a cancer patient where it may help but nicotinamide we showed back in 2002 is a really effective inhibitor of the sirtuins which are enzymes that you want to keep on it's the whole point of raising an ad and so we try to avoid nicotinamide while raising an ad”