Remaining metabolically healthy is sufficient to maintain healthy NAD levels as one ages, and supplements like NMN and NR are unnecessary and potentially harmful.

“if you want your nad levels to be healthy as you age you have only to remain metabolically healthy the problem is that most of your physicians don't know how to assess that they won't give you something like a continuous glucose monitor from a company like nutrisense or test your fasting insulin and if you happen to be metabolically unhealthy they won't have the answers for you because these are not taught in medical school we are never taught in medical school how to recreate metabolic health or reclaim metabolic health for a patient who has become diabetic pre-diabetic insulin resistant etc these are all synonyms in fact i was just listening to one of joe's recent podcast and the guest he had on seemed to assume that diabetes was an immutable condition and i thought that is [ __ ] diabetes is completely changeable metabolic health is completely attainable metabolic dysfunction is totally reversible your name pt enzyme can function well again my friends you can get the nad you need through the salvage pathway without taking nmn and nr and then depleting your methyl groups these things do not work well in the long term all of these supplements claiming to be longevity supplements by giving you nm and an nmr by giving you nmn and nr are [ __ ] become metabolically healthy know what it means to be metabolically healthy know how to reclaim your metabolic health i talked about that in so many podcasts so a couple of technical rabbit holes in this podcast but these are three really important concepts that i wanted to discuss and the overarching idea is yet again an animal-based diet wins as i've talked about before i'm a truth seeker when i'm wrong i will talk about it when i'm right i will tell you guys that i think i'm right and in this case i continue to think that i'm right about vegetables not being good for humans i continue to believe that i'm right about meat and organs being the center of a human diet i continue to believe that fruit is good for humans that fructose in the whole food matrix is not damaging for humans something i've talked about previously on other podcasts just a few weeks ago i continue to believe that honey is good for humans and often sought and i continue to believe deeply that getting out in nature in real sunlight with community and doing things that you value is critical to being a human animal out of your cage so think about the first set of things i talked about in this podcast non-protein amino acids present in legumes present in roots present in leaves being inserted into proteins four amino acids that are present in animal foods and leading to misfolding of proteins potentially causing autoimmune issues multiple sclerosis neurodegenerative disorders parkinson's als like syndromes this is a big deal why would you eat those foods and why would you not get enough protein in your diet from meat and organs to protect you against those misincorporations of these non-protein amino acids these proteinomimetic amino acids getting onto the trnas and leading to protein misfolding an animal-based diet is protective protective against neurodegeneration protective against als at least in associations in brazil and uruguay and many other countries because you are getting nutrients that you need people saying that animal protein ages you are missing the point here that not true that's really not substantiated by any studies and the animal protein is beneficial the animal protein is protective against these plant defense mechanisms so this is why an animal-based diet is so valuable for humans it gives you the nutrients you need in the most bioavailable forms with the least amount of toxins possible that is a formula for human thriving you do not need to eat ponsgum you do not need to eat chlorella or spirulina they also contain some of these non-protein amino acids specifically bmaa i feel sad that i sold it in college it didn't last long my father set me straight and i will never take afa or eat spirulina again perhaps chlorella has some uses for binding occasionally but in general your ancestors did not celebrate pond scum an overarching concept that i always talk about is the importance of being metabolically healthy know what your fasting insulin is wear a continuous glucose monitor from a company like nutrisense and you will have the tools or at least the information that you need to begin your journey with an animal-based diet with the idea of the remembering to reclaim your birthright to radical health get organs either fresh or desiccated like we make it hard in soil it's a critical part of this diet but i do not believe that nmn and nr are valuable for humans i think that they are going to mess up your biochemistry it's complex you can see the diagram on youtube if you weren't watching this if you want to refer back to it the paper is there for you guys if you want to see it nmn and nr will increase nam which is nicotinamide which will lead to consumption of methyl groups which will lead to biochemical imbalance if you go back to the podcast with david sinclair he kind of waffles on this and even admits that he is taking a methyl donor supplement because he's taking nmn and nr that is a formula for ruin long term because that will destabilize everything once”

“you do not need mn nmn and nr in my opinion they are [ __ ]”