NMN and NR supplementation can lead to biochemical imbalance by increasing NAM, consuming methyl groups, and destabilizing bodily functions long-term.

“nmn and nr will increase nam which is nicotinamide which will lead to consumption of methyl groups which will lead to biochemical imbalance if you go back to the podcast with david sinclair he kind of waffles on this and even admits that he is taking a methyl donor supplement because he's taking nmn and nr that is a formula for ruin long term because that will destabilize everything once”

“i do not believe that nmn and nr are valuable for humans i think that they are going to mess up your biochemistry it's complex you can see the diagram on youtube if you weren't watching this if you want to refer back to it the paper is there for you guys if you want to see it nmn and nr will increase nam which is nicotinamide which will lead to consumption of methyl groups which will lead to biochemical imbalance”

“I don't think that you want to take nmn or nr to increase your nad levels as you age that will lead to excess nicotinamide that will deplete methyl groups which can lead to all sorts of problems because there are hundreds of reactions that require methyl donors”

“So you see in a number of people actually on an MN is their homocyine level going up including me um I I stopped taking it when I saw this. I thought this is not I was taking about a gram of NMN for a while and then I saw my homoyine level going up. I think as a reflection of this this pathway and basically stopped it.”