Challenges exist in replicating NMN and NR efficacy in mouse models, potentially due to genetic background differences or delivery issues.

“we've struggled with this as well in my lab so you know it's been reported in this mitochondrial disease mouse by a collaborator of ours who i i trust their data right that that nmn could increase lifespan in that mouse model we've tried multiple times with both nr and nmn in that mouse model and been unable to to get these effects so i think these drugs are tricky uh from a from a biological efficacy perspective to there's something we don't understand about delivery or or uptake”