Peter Attia· MD
NR but not NAM restore NAD in heart.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
NR but not NAM restore NAD in heart.
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So nicotenoid ribocide is probably the kind of premium um NAD precursor in the sense that the NR kinace pathway gets upregulated in a lot of conditions of metabolic stress. So in the failing heart in a um damaged neuron nicotenomide ribocide kynise one and two genes get upregulated and so that's why NR you know works in a lot of mouse models in which nicotenomide doesn't work like in the heart failure experiments nicotenomide can't actually boost the NAD in the failing heart because in the failing heart it's overexpressing a gene called NMRK2 nicotenomide ribosite kynes 2.