The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there is a little bit of nicotinamide rye beside that gets into the blood that there's a little bit that gets into them into some of the cells not others so for example it can't cross the brain at all it's fairly decent at getting into muscle
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what is there can get into the muscle and there is a little bit that gets turned into nad
animal experiments suggest that there are trace amounts of that that will get into certain cells like muscle cells and be converted into nad but they're a physiologically meaningless amount of the nad that wound up in that muscle cell from taking that supplement
I'm assuming that you don't just need more nad in the liver correct wouldn't you want it also in the muscles or other cells