Supplementing with NR or NMN to increase NAD+ may deplete methyl groups through the excretion of methyl nicotinamide.

“so I will just add an asterisk of caution and anyone using NR nmn and we can talk about this as well anyone who is looking to increase their supply of nad in the body by taking they can send my right side or MMN do you think we should keep an eye on methylation and methyl groups because isn't it possible that we could use up too many of the methyl groups as we're getting rid of methyl nicotinamide and then we know that the methyl groups are needed to affect biochemistry with homocysteine with catecholamine degradation in the brain etc etc right so it it's anecdotal right now but to me it makes sense”