The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
when you take nr and nmn supplements and you don't correct anything else about your biology which is what the majority people do you will accumulate nam you will accumulate nicotinamide and that can lead to problems with methylation because excess nicotinamide must be methylated to be detoxified
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
so the potential risk is that you're sapping your methyl group supply and the reason is that like we said before part of this cycle is when you do generate nicotinamide you face the possibility that you have to methylate it and you have to pee out the methylated metabolite and then the question is well if you're taking a thousand milligrams or two thousand milligrams of NR a day which for the sake of putting some numbers on it the RDA for niacin is around 15 milligrams so we're talking yeah you are losing a lot of methyl groups