Peter Attia· MD
there's promise based on the animal experiments although there are in the human trials that they've done they haven't showed any benefit of doing this at all now what you mentioned Brenner I mean you didn't mention him by name but you mentioned chromatics tell me a little bit about their work I've looked at a couple of their human studies and they've done a couple of studies where they've characterized the metabolites that are produced when you take oral NR and they've done a couple studies where they tried to look for some benefits and didn't really find any so there's no benefits on glucose metabolism there's no benefits on lipid metabolism now were they doing these as kinetic studies or were they actually trying to look for phenotypic improvement in the first study they just took one person and they extensively characterized all the metabolites that were produced in three different compartments but then there were two and I don't know if this is comprehensive but in the studies that I looked at there were two other studies where they were measuring in different populations they were measuring things that you would relate to health like glucose and triglycerides and you're saying those things did not improve yeah in fact there's in one of the papers I believe it was two triglycerides went up a little bit and the potassium the serum potassium went down a little bit mean nothing that was that you wouldn't conclude anything from it mhm but it didn't it didn't look like it was doing anything good