The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So, in the case of hearing loss, it’s dependent on some really uniquely sensitive cells in the inner ear. But, generally, there’s been sort of an assumption in the field that most of the effect of nicotinamide ribosides, protective effect, are dependent on sirtuin-1. I think in… Yes. And, in some case, it is. In this particular case, noise-induced hearing loss, it was really clearly sirtuin-3.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
But with nicotinamide riboside, so if you’re going to a rock concert… Yes. In mice, it actually had an enormous effect, and we found that this effect was dependent on sirtuin-3, so in sirtuin-3 knockout mice, the effect was lost.