The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
don't you dare eat pepper because the piperine and the pepper is going to inhibit udp gluconasal transferase which is just one of the phase two detoxification enzymes that allows you to put a glucuronide moiety on molecules like curcumin that your body does not want
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
If you are eating moldy food or you are exposed to things that your body wants to detoxify with glucuronidation and you eat black pepper, you are inhibiting or decreasing your body's ability to do that, the level of UDP-glucuronosyltransferase. Curcumin being one of those, there are many others, and you're making this problem worse. And as Evan said, you're getting recirculation, enterohepatic recirculation, of things like xenoestrogens or estrogens from the body, endogenous estrogens, and you're getting all sorts of problems.
piperine is a substance found in black pepper a plant seed that inhibits udp glucuronasal transferase