Sphingoise acting on saturated fat-enriched LDL inside the intima rapidly produces ceramides, which cause these particles to clump together more readily.

“There's an enzyme called sphingoise which when it acts on a saturated faten enriched LDL molecule inside the inima it rapidly produces ceramides and those ceramides actually for a lack of a better term can collapse these particles and cause them to clump together much more much more readily.”