Lectins binding to the gut's brush border can damage the mucous layer, allowing gram-negative bacteria to proliferate and cause inflammation and dysbiosis.

“so it's actually not interaction with the bacteria it's an interaction with the intestine directly these this phytohuman gluten these lectins are directly toxic to our intestines they show here phytohuman gluten and feeding has been also observed to affect small intestinal growth in a negative way these effects are believed to result from changes in the microflora induced by the presence of pha in the diet as germ-free animals do not display the same changes in conventional animals they um they impaired growth so here's what i said earlier causes reduced growth rates in several animal species when incorporated at point five to five percent of dietary feeding lactane feeding results in diarrhea impaired nutrient absorption growth rate inhibition can even lead to eventual death of pha fed animals so what this paper actually starts to suggest is that the pha is able to bind directly so phytohemaglutin is lectin from beans and other lectins probably as well lentil lectins probably lectins from elderberry are able to bind directly to the mucosal surface of the intestine at the brush border membranes and that is probably the problem i think that what's going on here and there are multiple studies to suggest this now is that lectins are binding directly to our gut directly to the brush border directly to the small intestinal villi and probably affecting the production of mucin by the goblet cells”