Carbohydrates provide a robust fed state signal and do not induce hyperglycemic stress, which can create inflammation and oxidative stress.

“state signals of how much energy do I have and the relative balance of being under stressed or overstressed in my view is going to be nourished by an amount of carbohydrate that provides a more robust fed state signal but doesn't induce hyperglycemic stress which I think we would probably agree is itself a stressor and there's odin's for that as well there's evidence in in carbohydrate based diet over feeding that that creates inflammation and you know evidence of oxidative stress”

“a ketogenic diet is going to provide signals of being in the fed state but they're not going to be as robust as signals from a carbohydrate inclusive diet”

“carb availability is one of the main determinant here”