In populations where over 5% of calories are from linoleic acid, it may be difficult to observe increased oxidative products of linoleic acid metabolism even with higher intake.

“if everyone in a room is smoking you're in a dirty you're in a dirty environment and if everyone in the population is eating more than five percent of their calories is linoleic acid and we believe that the cutoff point for human pathology is somewhere between two and four percent then everyone is already sick and if you give them more than five percent is it possible you're not going to see an effect”