We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
there's pretty good evidence that even a moderate dose is found in diets soy isoflavones which are a polyphenolic molecule can mimic estrogen and do many bad things including anti-thyroid effects similar to the isothiocyanates we were talking about earlier
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even moderate intakes of isoflavones from soy can cause pretty significant endocrine disruption and i will show some studies which corroborate that and i note a number in the book as well so the first study is titled goitrogenic and estrogenic activity of soy isoflavones
in this paper you will see that just in the abstract they say these are phytoestrogens with potent estrogenic activity genistein diazin glycetine are the most active isoflavones found in soybeans there are many problems with soybeans not the least of which is isoflavones later in this podcast which is now getting to be pretty long and already in depth uh we will talk about the other problems with soybean oil specifically linoleic acid and polyunsaturated fatty acid in this paper they show these isoflavones which do mimic estrogen they look a lot like estrogen visually and they show that they are easily absorbed you can see they are easily absorbed showing up in the plasma of humans with consumption uh this is genestyne this is diazine diazine and you can see that these these really do affect human plasma levels when we eat them and they are known to bind these receptors and cause both estrogenic and um anti-thyroid effects at normal doses
genistein is the major soy isoflavone it's also found to have a frankly estrogenic effect in women and they look at observational studies in animal and humans suggesting a link between soy consumption and goiter which is an activity independent of estrogenicity this is iodine deficiency which greatly increases soy's anti-thyroid effects