Mice engineered without TLR4 showed decreased lipid peroxidation, liver damage, and inflammation when fed high amounts of fructose.

“you're basically seeing if you the endotoxin here is likely the major contributor in the fructose feeding studies for the dysfunction than the fructose itself because when you don't have the inflammatory pathway working and mice that are fed 30% fructose you don't actually see the same levels dysfunction in uh triglyceride accumulation Etc”