Glucose phosphorylation to pyruvate does not cause a significant drop in intracellular phosphate to trigger the AMPD pathway due to an autoregulatory mechanism.

“you still have to phosphorylate glucose during its metabolism why is it that the phosphorylation of glucose during its metabolism to pyruvate doesn't result in a strong enough drop in intracellular phosphate to cause the same problem because uh the reaction stops whenever there's um the phosphate and atp levels start dropping a little you have that autoregulatory thing with the there's an autoregulatory thing with it the enzyme stops functioning it's inhibited and then it allows the atp levels to stay normal”