Individuals who are already highly trained or have normal levels of certain hormones or are already studying a subject intensely will see minimal benefit from small additional increases in those factors.

“Well, because you're already sort of on the asmtote, right? It's like anything else. You know, you take someone who's never had any uh value of it and uh, get a big benefit. Uh, give a mouse that has no leptin, just a tiny little bit of leptin, and it immediately starts to slim down quite a lot. Give a mouse that has a normal amount of leptin a little bit more, you're going to observe almost nothing.”