Paul Saladino· MD
we can use other short chain fatty acids like isobutyrate just as easily as we can use butyrate for the colonic epithelial cells so i don't think that we need to be hyper focused on butyrate coming from plant fiber we can get isobuterate from protein and that's just as easily going to trigger all the receptors that butyrate will trigger in the gut and it can be used as colonic epithelial cell fuel in the same way in the gut