Macronutrient composition, specifically subsets of amino acids or sugar reduction, may independently influence healthspan beyond caloric reduction.

“What's your take on the role of the macronutrients here and I'll I'll pass it to two candidates to consider the first being a subset of amino acids whether it be methionine tryptophan um leucine would be candidates to consider um and then other things such as sugar um again the the the Wisconsin half of the monkey experiment certainly suggested that a reduction in sucrose perhaps independent of calories could have played a role but it's difficult because we can't disentangle it from the weight loss and other things um but what do we know about amino acids and the role we certainly know that mtor which you brought up a moment ago is an amino acid sensor um so how do you think that fits in independent of calories perhaps”