Gastric bypass surgery can improve satiety and insulin sensitivity by bypassing the duodenum and its cannabinoid receptors, thereby reducing hunger signals from linoleic acid.

“what happens is linolic acid breaks down into those in the human gut and there are receptors for those cannabinoids in the human gut which is crazy and it's corroborated by the fact that you can fix all this by a surgery that we do called gastric bypass so the way gastric bypass works is you cut the stomach at its intersection with the dadum and you attach the stomach further down on the small intestine maybe somewhere in the dunum or the distal dadum so basically what you're doing is you're creating a blind Loop of bow does that make sense you have the dadum where it attaches to the stomach and you're taking this dadum you're making a blind Loop of bowel you're bypassing all these uh and and all these endogenous cannaboid receptors and you connect the stomach down lower right so if you eat linolic acid now you missed all of these receptors that fixes satiety like almost instantly people become insulin sensitive overnight with a surgery they lose weight immediately their satiety goes through the roof because you're bypassing all those receptors”