The FDA does not recognize any safety differences between high fructose corn syrup (HFCS 42 or 55) and other similar nutritive sweeteners like sucrose or honey.

“the FDA does not believe that there are any problems with high fructose corn syrup it's high fructose corn syrup less safe than other sweeteners we are not aware of any evidence including studies mentioned above that there's any difference in safety between foods containing high fructose corn syrup 42 or high fructose corn syrup 50 5 and from containing other similar amounts of nutritive sweeteners with approximately equal glucose and fructose content such as sucrose honey or other traditional sweeteners”