Phytohemagglutinin (PHA) from red kidney beans can cause bacterial overgrowth and inflammation by altering the small intestine's mucosal surface.

“small intestinal growth caused by feeding rat uh feeding kidney bean phytohemoglobin liked into rats this is suggesting that in the small intestine you're getting growth that could lead potentially to the formation of tumors”

“now what's interesting is if they give phytohemaglutinin to rats and mice those rats and mice do not thrive they lose weight they they do not do well at all”

“pha which is phytohemaglutinin caused fecal protein fat and mucous glycoprotein levels to increase in germ-free animals it increased to general mucous crypt death and crypt mitotic activity and so they're saying pha stimulated growth of rats small intestine when present in the diet or instilled into the bowel lumens so it was causing inflammation and it was potentially causing issues within these rat guts when they're giving them this lectin in kidney beans”

“So, I think that the compelling hypothesis here is that these phytohemagglutinins from red kidney beans, these lectins in plants, perhaps more broadly, may damage or cause issues in the mucosal-producing cells, the goblet cells of the gut, and they may decrease the mucosal layer of the gut.”

“So, PHA is the lectin found in red kidney beans. They say that there are bacterial overgrowth happens in the small bowel of the rat when they give them PHA.”

“i think that the compelling hypothesis here is that these phytohim and glutamines from red kidney beans these lectins in plants perhaps more broadly may damage or cause issues in the mucosal-producing cells the goblet cells of the gut and they may decrease the mucosal layer of the gut they do appear to lead to this induced overgrowth of the small intestine and inflammation”

“what appeared to happen was that the mucosal surface changed when the phytohuman glutenants were administered leading to contact between intestinal bacteria and the epithelium which led to inflammation”