Citrate is converted into acetyl-CoA, a precursor for acetylcholine, which is important for REM sleep, learning, memory, and attention.

“What's a little more interesting in my mind is that citrate gets converted into acetal coa which among other things is one of the two precursors for the neurotransmitter acetylcholine. While there are many different sodium dependent citrate transporters across several regions of the brain, it is unclear whether citrate directly gets transported across the bloodb brain barrier. However, at the very least, we know that citrate gets converted into pyuvate, which does cross the bloodb brain barrier. In the brain, acetylcholine is important for REM sleep learning memory attention and more.”