Rhonda Patrick· PhD
It's also been shown that citrate in the brain is a source of acetal COA that is also used for acetylcholine synthesis.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
It's also been shown that citrate in the brain is a source of acetal COA that is also used for acetylcholine synthesis.
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What's a little more interesting in my mind is that citrate gets converted into acetal coa which among other things is one of the two precursors for the neurotransmitter acetylcholine. While there are many different sodium dependent citrate transporters across several regions of the brain, it is unclear whether citrate directly gets transported across the bloodb brain barrier. However, at the very least, we know that citrate gets converted into pyuvate, which does cross the bloodb brain barrier. In the brain, acetylcholine is important for REM sleep learning memory attention and more.