High histamine levels from wine and cheese can cause symptoms like runny nose, irritability, and sleep difficulties, and require methylation for elimination.

“then you have histamine a lot of people with allergies or drinking wine and listen folks this is a big one for a lot of you if you're drinking wine and she eaten cheese and you like you you get you know what silently runny nose and you can't fall asleep and you actually get a little bit irritable and read and written are in space that's high histamine levels and so if you take certain nutrients or eat certain foods that can process that histamine for you then you can fall asleep no problem you're not that you can be able to enjoy your wine and your cheese and you're not gonna get irritated and you're not gonna get the runny nose with a nose please with red face you're like well I'll talk more about that while it's in the book it's a dirty Dao gene it's right there but I'm just telling you that histamine needs methylation to get eliminated out of the body”