Paul Saladino· MD
fructose gets metabolized down a few different pathways in the liver predominantly fructose has an aldehyde pathway so it has an alcohol pathway so all the byproducts of alcohol are pretty well there in the liver it has a uric acid effect as well in the fact that it inhibits you that uric acid byproduct is here but it's a whole lot of things related to a thing called nitric oxide nitric oxide is a major regulator of circulation to the brain to all of our blood vessels hypertension and it's also involved in the inflammatory cascade of how Axel's migrated into the into damaged tissue it's also got a major pathway of too much fructose going down into the cool ldl-cholesterol pathway so that's that I don't know it in fact a small dense LDL is one of the end products of it so which we seem to think is actually of the major component involved in arterial disease micro vascular disease so access levels of fructose correlated with higher levels of small dense LDL is possibly through insulin resistant mechanisms like we can talk about it's got pathways through the fixing similar resistance so Fronteras conductors cause insulin resistance it's tied up at the muscle level it's got involved in the leptin effect as well it also has a hypothalamic response it actually goes to the nucleus accumbens which is the addiction center it's a really important molecule and the small amounts that we would normally have in nature which is eating seasonal fruit are probably okay so if you are literally hunt together and you eat your seasonal fruit and you remembering that fruit in nature is there to be eaten in fact stuffed in your face so you can actually eat or eat which gets turned into fat for winter hibernation and that's what if you think about fruit and fructose and think about I'm eating it to get fat for winter then it drives all those behaviors it actually gets stored as fat there's effects on the brain to actually make you eat more than you possibly can and in Australia what opossums that will come through and scrip of fruit tree bear and a knife about two or three days before the fruits actually ready for us to it because they wanted to get fat bears will want it to get fat for winter hibernation so just think about what fruit does it drives behavior to get fat so forget all the meat that you know all the biochemical pathways are there and if you cared too much fruit you see monkeys in the wild that actually get drunk yeah and if you hate too much sugar guess what a few hours after you eat in it you get tropic you know you get fall asleep so and we see it with kids at a party you know if you give kids at a party sugar they'll go on run around crazily and then a few hours later that cranky and tired and and so you can almost see that drives behavior agitation few hours later makes you want to lie down and rest so that's sugar but just imagine all you know if we just imagine if we gave everyone on the planet sugar at the one time well