Highly palatable, calorie-dense foods can cause neurobiological devaluation of less preferred foods in the brain's reward circuits.

“they actually neurobiologically devalue if you look at the circuits activity of their reward circuits they devalue once they've been exposed exposed to the preferred food they devalue the less preferred food so it no longer satisfies them no longer motivates them in the same way that it did before they were exposed to the highly preferred food”

“our brains are set up to not be satisfied with ordinary stuff once we have gotten good stuff is a simple way to put it and uh Michael crashes did a really interesting Neuroscience study on this in mice mice normally they eat these refined food pellets that would be like the default diet but they much prefer these calorie dense refined high-fat pellets and if you give that to them they will very much preferentially eat that over the healthier unrefined pellets and what happens is they actually neurobiologically devalue if you look at the circuits activity of their reward circuits they devalue once they've been exposed exposed to the preferred food they devalue the less preferred food”