Paul Saladino· MD
moderate amounts of fructose i do not believe are harmful in any way shape or form when it comes to gout provided that you are metabolically healthy that's what you guys get when i get super excited about this stuff i just start singing these are important to know the difference between fructolysis fructolysis and glycolysis glycolysis goes through these steps phosphofructokinase here is the rate limiting step fructose is going to bypass that and can go through these steps here and go to acetyl coa without any impediment which means you can accumulate triglycerides and dldls if you have tons of fructose but moderate amounts of fructose that we would have found seasonally in the environment i don't think are a problem for humans and we've seen that in the hadza we've seen that in tons of cultures who include fructose in their diet but don't have gout