Animal studies suggest that high fructose corn syrup causes significantly more weight gain than sucrose, even when overall caloric intake is matched.

“high fructose corn syrup causes characteristics of obesity and rats increased body weight body fat and triglyceride levels no surprise there what is important to note is that when sucrose was given alongside of this equally caloric there were differences and the hyper Coast corn syrup caused more problems”

“high fructose corn syrup prompts considerably more weight gain than sucrose you can see here rats with access to high fructose corn syrup gain significantly more weight than those with access to table sugar even when their overall caloric intake was the same”