Leptin administration can increase daily energy expenditure by approximately 100 kcal in individuals who have lost weight.

“we've done experiments subsequently in which we've injected leptin into those individuals none of them has a genetic revisional so they're just engineers they just wait reduce normal individuals we've put leptin back into them by injection to raise the blood level back to where it was before they lost their body weight so these are very low doses of leptin and that intervention will restore their energy expenditure back to where it was before they lost the body weight even though they're now still maintaining the lower body way”