The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Normally, we found that isoflavonoids from diet are degraded by the microbiome to compounds which swim into adipose cells and signal to them to release more heat and store less fat when we are exposed to an obesogenic diet.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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So the bacteria normally...actually generate these flavonoids for more complex flavonoids by chemically modifying them. Once this obesity and then successful dieting occurs, the change in the microbiome that is so persistent means that the microbes are no longer able to generate these compounds, and this leads to a cascade of events that results in more fat accumulation per given diet leading to exaggerated weight regain.
But when these compounds were missing after a successful diet, the adipose cells, the fat cells were no longer given the signal to release heat and not to store fat, and now they were storing more fat and making the mice more obese as compared to non-yo-yo obesity mice.
Now, in order to try and study and understand what the drivers of these behaviors are, we looked into tens of different parameters that can be measured in mice after they successfully diet to look for something in the mice following a successful diet that could store a bad memory of their previous obesity.