Early animal model studies suggest leptin signaling in the hypothalamus is not broadly impaired in obesity, indicating the issue may lie with higher leptin levels required to achieve the same signal.

“and if you look at leptin signaling there's there were some early studies done in animal models suggesting that if you're just looking bra if you mash up the hypothalamus and you look at what's going on in it broadly on average you find that the amount of leptin response the intracellular signaling cascade that's activated by leptin is not really impaired in animals with obesity it's like it's like they're getting the same leptin signal from a much higher level of leptin”