In animal models with obesity, the intracellular signaling cascade activated by leptin in the hypothalamus is not significantly impaired on average, suggesting the issue is not a general failure of leptin response.

“if you look at leptin signaling there's there were some early studies done in in animal models suggesting that if you're just looking bro if you mash up the hypothalamus and look at what's going on in it broadly on average you find that the amount of leptin response the intracellular signaling cascade that's activated by leptin is not really impaired in animals with obesity”