Individuals with lower starting leptin levels lost more weight when given leptin.

“now subsequently they went back and did um an reanalysis of that clinical trial and ask what if you take all of these people and stratify them according to their starting leptin level so some people have relatively low levels of leptin some have higher some have really high levels of leptin and then ask if we reanalyze the data um how uh how effective is leptin and as you might expect the people with the lowest levels of leptin they lost the”

“and alternatively after weight loss so after you've lost a lot of weight your leptin levels plummet they become very low and that part of the reason it's a big part of the reason it's so difficult to keep weight off is because those leptin levels are so low and so it's been thought for a long time that that that is a scenario where treat treating people with leptin uh uh could be really useful to help them keep the weight off”

“so let's say my fed level is 2 or 3 or 4 my fasting level is less than 2 if you injected me with enough leptin such that let's just say my level was now 100 the level that you would see in the highest fed obese patient what would that do to me based on the studies that have been done the the so called leptin trial not very much so interesting”

“there was a major trial of the use of leptin as a therapeutic agent in obese individuals and neither the obese individuals or the lean individuals who were in the study as controls responded very much to raising blood levels as much as tenfold above where they were normally located in those”