Time-restricted feeding can lead to physiological improvements in obese mice, with blood biomarkers returning to near-normal ranges.

“So in rodent studies what we have seen when we take already fat mice, who have been eating a really unhealthy diet for a long period in their life, and then put them on a time-restricted feeding paradigm, they don't become, like, lean mice in terms of body weight. They become overweight, not normal. But surprisingly they're biochemically...or physiologically they're more healthy because their blood biomarkers for glucose, cholesterol, triglycerides, they come to almost normal range.”