Eating more seed oils may stimulate the CB1 receptor in the brain, potentially leading to an anti-obesity effect.

“what interests me, though, this anti-obesity effect that comes with a antagonism or inverse agonism at the level of the CB1 receptor in the brain. And we know that eating more seed oils, at least in mice, tickles that receptor more because endogenous cannabinoids, or I should say, because cannabinoids, 2-AG and anandamide, appear to be overproduced.”