Peter Attia· MD
so in the same way that people can develop insulin resistance where it takes more insulin to do the physiological jobs in the body people with obesity require more leptin for the hypothalamus to be satisfied
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so in the same way that people can develop insulin resistance where it takes more insulin to do the physiological jobs in the body people with obesity require more leptin for the hypothalamus to be satisfied
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and the concept that has been invoked to explain this is leptin resistance