Paul Saladino· MD
i do not believe in excess omega-3 supplementation for a variety of reasons omega-3 can get oxidized and there's a potential that too much omega-3 could also affect the f10 ratio but that's a story for their day
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
i do not believe in excess omega-3 supplementation for a variety of reasons omega-3 can get oxidized and there's a potential that too much omega-3 could also affect the f10 ratio but that's a story for their day
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we are forming alkenals we're forming alpha beta unsaturated ketones and we are forming hydroperoxides like i showed you there so that's a bad thing you don't want to over supplement with omega-3s they are not entirely benign
i also think that we don't need to go out of our way to get lots and lots of omega-3 and if you really look at the literature there's not a whole lot of benefits to excess little omega-3 in fact there are many harms to excess omega-3
I worry personally about excess omega-3 leading to lots of polyunsaturated which have to be controlled from an oxidative perspective
if you supplement too much with Omega-3s you can see increased lipid peroxides so you don't want to overs supplement with Omega-3s