Pure EPA at four grams may reduce cardiovascular events through mechanisms other than lowering triglycerides or ApoB, potentially involving resolution of inflammation and heart rate variability.

“why in the world would four grams of EPA reduce events especially as you said when it's not the obvious mechanism of hey we're gonna drop triglycerides which all things equal should drop a poby and by the way you're seeing a greater magnitude of event reduction than you're seeing with aspirin so the pure anti platelet effect also seems a bit counterintuitive what else do you think is going on here right right it's not enough whatever role inflammation and it's such a a slippery word that's thrown around so much but EPA definitely gives rise to molecules that are pro of resolution of inflammation so inflammation starts the EPA will will shut it down to whatever extent a cardiovascular event is is precipitated by an inflammatory event the omega-3 EPA could could participate in that it could stop it”