High doses of DHA can raise LDL cholesterol, particularly in individuals with hypertriglyceridemia, though the clinical significance is unknown.

“instead of patients completely controlling their diet by that time we were able to because omega-3 supplements concentrated pills were now becoming available and so we did some studies just giving 18 capsules so we were giving 6 grams a day of epa and DHA in capsule form without changing anybody's diet”

“that they don't lower cholesterol in fact in some people at high dose they will raise cholesterol”

“DHA does raise particularly in people or hypertriglyceridemia taking fairly high doses of DHA there will be an LDL raising effect whether that's a bad thing or not nobody knows but it's been observed”