Knocking out coagulation proteins in mice is embryonic lethal, while knocking out proteins involved in calcium removal from arteries leads to arterial calcification, cardiovascular problems, cancer, and bone/soft tissue issues.

“when she looked in the literature the proteins that are involved in coagulation when you knock those proteins out in mice they're embryonic lethal big surprise it's required probably for short-term survival the other proteins that are involved in removing calcium from the bloodstream bringing it to the Bone and tissues like osteocalcin Matrix glow protein those phenotypes are not lethal when you knock them out in mice however they lead to buildup of calcium in the arteries they lead to cardiovascular problems and they lead to cancer they lead to um bone uh problems with osteoporosis and also uh it leads to soft tissue problems”