A daily prednisone dose of 5mg is associated with significant reductions in bone mineral density and increased fracture risk within 3-6 months of initiation.

“people who are familiar with long-term use of steroids might recognize that a dose of predinazone of five milligrams a day is not enormous. Um you know a prennazone dose of 5 milligrams a day is I mean I think it's actually still a kind of big dose because it's about the physiologic equivalent of how much hydrocort you know how much cortisol a person makes. Um but nevertheless, you know, that amount is associated with significant reductions in bone mineral density and an increased risk fracture within as little as 3 to 6 months of initiation.”

“people who are familiar with long-term use of steroids might recognize that a dose of predinazone of five milligrams a day is not enormous. Um, you know a prennazone dose of 5 milligrams a day is I mean I think it's actually still a kind of big dose because it's about the physiologic equivalent of how much hydrocort you know how much cortisol a person makes.”