Prolonged high-intensity exercise over 45-50 minutes can deplete circulating buffers, leading to increased oxidative stress and potential damage to blood vessels and the heart. — Whalespan
Prolonged high-intensity exercise over 45-50 minutes can deplete circulating buffers, leading to increased oxidative stress and potential damage to blood vessels and the heart.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“we have a lot of circulating buffers in there to basically neutralize those free radicals but we we deplete that after 45 to 50 minutes of high intensity exercise and there's good animal studies showing and human studies showing that diastolic function improves for the first 30 minutes of exercise and by 50 minutes or 60 minutes it starts to worsen and the endothelial function will start to worsen too after you've depleted those antioxidants after 45 or 50 minutes you start like searing the inside of your vessels those endothelial sensitive endothelial linings with high high free radical levels and you also start over taxing the heart muscle”