The PINK/Parkin pathway marks damaged mitochondria for destruction.

“So the PINK/Parkin pathway is one pathway among others, that allows for marking mitochondria that are damaged for destruction. And so, inhibition of this pathway leads to the accumulation of malfunctioning mitochondria with major consequences for the cell that harbours cells' mitochondria because all of a sudden bioenergetic metabolism becomes inefficient, reactive oxygen species are produced, and as you know, mitochondria are latent bombs in the sense that they enclose potentially dangerous proteins that once released will activate the apoptotic machinery and cause cellular suicide.”