Paul Saladino· MD
the Fora trial actually showed that when you reduce LDL the mortality went up in that group and I will show you this is not a benefit this is a worsening of mortality in the fora trial
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the Fora trial actually showed that when you reduce LDL the mortality went up in that group and I will show you this is not a benefit this is a worsening of mortality in the fora trial
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and in fact there was a non-significant increase more people in that arm involving pc9 Inhibitors died than people in the placebo arm
And in that trial and all the patients in this trial were on statins and they either had PCSK9 inhibitors added or they were in the placebo group. They didn't get PCSK9 inhibitors. And more patients overall died in the group that got the PCSK9 inhibitors.